Volume 1 Issue 2
Cost-Utility Analysis of Timolol for the Treatment for Open-Angle Glaucoma
Gary C. Brown, MD, MBA*, Joshua D. Stein, MD, MSc, Melissa M. Brown, MD, MBA, George L. Spaeth, MD, Richard P. Wilson, MD
An information system integrating patient perceptions to quantify patient preference-based comparative effectiveness, or patient value gain (improvement in quality-of-life and/or length-of-life) of interventions across medicine is highly desirable. It facilitates use of the highest quality drugs and other interventions. Concomitantly, identifying less expensive comparator interventions that confer the same or greater patient value can maximize the efficient use of scarce healthcare resources.
The Role of PDGF Antagonists in the Treatment of Neovascular Age-Related Macular Degeneration
Christina Y. Weng, MD, MBA*
Platelet-derived growth factor (PDGF) plays an important role in the angiogenic process of diseases such as neovascular age-related macular degeneration (NVAMD). Currently, the primary treatment for NVAMD is intravitreal anti-VEGF therapy. However, some patients experience either a lack of response or an incomplete response to anti-VEGF injections. Emerging research of PDGF antagonists suggests that this class of anti-angiogenic agents may be beneficial when administered in combination with anti-VEGF in the treatment of patients with NVAMD.
Subthreshold Micropulse Laser Photocoagulation in the Management of Central Serous Chorioretinopathy
Nisreen S. Ezuddin, BS, Nicole L. Lanza, MEd, Christina Y. Weng, MD, MBA*
Central serous chorioretinopathy (CSCR) is a condition characterized by serous retinal detachment with one or more leakage points in the choriocapillaris. The pathophysiology of CSCR is not completely understood, but its manifestations can be visually debilitating. While many cases of CSCR spontaneously resolve, some patients experience persistent or recurrent disease. Subthreshold diode micropulse (SDM) laser treatment has a potential role in the treatment of CSCR. This review will focus on the use of micropulse laser as a treatment modality for patients with this condition.
Bibliometric Analysis of the United Kingdom’s Contribution to Scientific Literature in the Field of Optometry
Francisco J Povedano Montero, B Optom MSc*, Francisco López-Muñoz, MD, PhD,Fernando Hidalgo Santa Cruz, OD, PhD, FAAO
Optometry is a relatively young discipline that has undergone major developments in recent decades, with English- speaking countries predominating in this scientific field, particularly the United States and the United Kingdom. There has been some controversy with regard to the origin of the word “optometry,” which seems to have first appeared in 1759 in the work “Treatise on the Eye, the Manner and Phaenomena of Vision.” by William Porterfield.
Intraocular Smokeless Gunpowder Pellet from Explosion of .22 Caliber Bullet
Kishan Govind MD, Jacob C. Meyer MD, Timothy M. Martin MD, Craig M. Greven MD*
We present a single case report of a 15 year old male who was hit in the face and eye with a spray of debris from an exploding bullet. Two orbital CT scans (the current standard for assessing for intraocular smokeless gunpowder) were negative for intraocular foreign body; however B-scan ultrasound revealed a pellet, later determined to be smokeless gunpowder in the anterior vitreous of the right eye. Henceforth, this case report demonstrates the applicability of b scan ultrasound in detecting intraocular smokeless gunpowder even in instances when orbital CT scans are negative for an intraocular foreign body.
Albumins and Carotenoids of the Human Fetal Vitreous Body and their Morphogenetic Role during Midgestation
Ina G. Panova*, Alexander S. Tatikolov, and Olga G. Stroeva
The vitreous is a transparent, highly hydrated gel located between the lens and the retina. In the adult vitreous carotenoids are absent. At 15–28 weeks of gestation the molecular composition of human fetal vitreous is characterized by twenty fold increase in the albumin content as compared to that in the adult vitreous, and by the presence of two transitory molecules – lutein and alpha-fetoprotein. A strong correlation between the albumin and lutein concentrations was found. The organizing molecule of this complex is albumin. The morphogenetic roles of albumin, alpha-fetoprotein and lutein in the human eye development and physiology are discussed.